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Apexbio Technology LLC FK866 (APO866) 658084-64-1 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A43815.1

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FK866 (APO866 CAS 658084-64-1) is a small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme involved in NAD biosynthesis FK866 inhibits NMPRTase with reported IC50 values ranging from 0 09 to 27 2 nM Due to elevated NAD turnover in cancer cells inhibition of NAD synthesis selectively induces cell death in cancerous cells FK866 reduces ATP production by decreasing cellular NAD availability resulting in mitochondrial membrane depolarization and caspase-independent cell death Preclinical studies demonstrate activity against hematologic cancer cell lines including AML with minimal toxicity to normal hematopoietic progenitors FK866 suppresses tumor growth in vivo and prolongs survival making it useful in oncology research related to NAD metabolism

Catalog No. 50-000-62452


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