LifeSensors Tandem Ubiquitin Binding Entities (K63 TUBE) FLAG 50µg

Supplier:  LifeSensors UM06040050

FLAG K63 TUBE is a high‑affinity reagent designed to selectively isolate and enrich K63‑linked polyubiquitinated proteins. It contains multiple ubiquitin‑interaction motifs connected by a rigid linker, enabling strong and highly selective binding to extended K63 chains—up to 10,000‑fold more selective than for K48 or K11 linkages. When expressed in vivo, the peptide protects K63‑linked chains from degradation and inhibits K63‑dependent cellular processes. Coupling the peptide to a FLAG tag creates a powerful tool for isolating, purifying, and characterizing K63‑modified proteins without requiring ubiquitin mutants, tagged ubiquitins, or DUB inhibitors. The isolated proteins can be analyzed by Western blot, mass spectrometry, or other biochemical methods. (FLAG is a registered trademark of Sigma-Aldrich Corporation LLC)

Catalog No. 50-103-7777