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Medchemexpress LLC Flavokawain C | 37308-75-1 | 20 MG
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Supplier:  Medchemexpress LLC HYN244520MG

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Flavokawain C is an orally active natural chalcone that inhibits the proliferation of various cancer cells through multiple mechanisms.

  • Inhibits cancer cell proliferation
  • Upregulates GADD153, p21, and p27
  • Modulates Akt and JNK phosphorylation
  • Activates caspase subtypes; induces PARP-1 cleavage
  • Elevates intracellular ROS; induces apoptosis
  • Activates AMPK/mTOR pathway; induces autophagy
  • Inhibits glycolysis (decreases GLUT1 and HK2)
  • Reduces angiogenesis (decreases Ang-1 and VEGF)
  • Increases γ-H2AX levels; induces DNA damage
  • Shows anti-tumor activity in mouse xenograft models

Catalog No. 50-004-18344


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