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Selleck Chemical LLC Flavopiridol (Alvocidib) HCl S2679-1g
Supplier: Selleck Chemical LLC S26791G
Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1 CDK2 CDK4 and CDK6 with IC50 of 40 nM in cell-free assays It is 7 5-fold more selective for CDK1/2/4/6 than CDK7 Flavopiridol is initially found to inhibit EGFR and PKA Flavopiridol HCl induces autophagy and ER stress Flavopiridol HCl blocks HIV-1 replication Phase 1/2
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