Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC Flavopiridol (Alvocidib) | 146426-40-6 | 99.4% | 401.84 | 100 MG
Supplier: Medchemexpress LLC 100MGHY10005
Flavopiridol (Alvocidib) is a broad-spectrum and competitive inhibitor of cyclin-dependent kinases (CDKs), effectively inhibiting CDK1, CDK2, and CDK4. It induces a distinct pattern of ER stress in CLL cells, contributing to cell death through IRE1-mediated activation of ASK1 and potentially downstream caspases. This compound also leads to potent upregulation of several primary response genes (PRGs) with both immediate and long-term effects on their expression. Furthermore, Flavopiridol inhibits cyclin E1 and induces apoptosis.
- Broad-spectrum and competitive inhibitor of CDKs
- Inhibits CDK1, CDK2, and CDK4
- Induces ER stress in CLL cells
- Contributes to cell death via IRE1-mediated activation of ASK1
- Upregulates primary response genes
- Inhibits cyclin E1
- Induces apoptosis
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?