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Selleck Chemical LLC Flavopiridol HCl 10mg 131740-09-5 NSC 649890 HCl, alvocidib, L86-8275, HMR-1275, DSP-2033
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Supplier:  Selleck Chemical LLC S267910MG

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Flavopiridol HCl (NSC 649890 HCl, alvocidib, L86-8275, HMR-1275, DSP-2033) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2. *For Research & Development use only.  Product is not intended for drug, household, or human consumption.

Catalog No. NC0458108


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