Medchemexpress LLC Flonoltinib TFA | 2928093-29-0 | 98.0% | C27H35F4N7O3 | 10MG

Supplier:  Medchemexpress LLC HY130247A10MG

Flonoltinib TFA is the trifluoroacetate salt of a potent, orally active small-molecule inhibitor of JAK2 and FLT3 kinases, used for preclinical oncology research. It exhibits low-nanomolar potency, induces apoptosis and cell-cycle arrest in cancer cell lines, and has shown antitumor activity in animal models.

• Low-nanomolar potency against JAK2 and FLT3 (JAK2 IC50 0.7 nM; FLT3 IC50 4 nM).
• Activity against JAK1 and JAK3 (IC50 26 nM and 39 nM), useful for kinase profiling.
• Supplied as the TFA salt, solid, yellow to orange, suitable for formulation studies.
• High reported purity (~98%), supporting reproducible biological testing.
• Water solubility reported (33.33 mg/mL; may require ultrasonic), aiding assay preparation.
• Storage recommendations: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
• For laboratory research use only; not for human therapeutic use.

Catalog No. 50-002-60135