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Cayman Chemical FloxurIdIn 100mg
Supplier: Cayman Chemical 14154100 MG
An active metabolite of 5-fluorouracil; induces DNA double-strand breaks in thymidylate synthase-deficient FM3A cells, as well as increases dATP levels and decreases dTTP and dGTP levels in wild-type thymidylate synthase-expressing FM3A F28-7 cells at 1 µM; inhibits the proliferation of L1210 and HeLa cells (IC50s = 1.1 and 9.4 nM, respectively); reduces tumor growth by 86.3% in a S180 murine sarcoma model at 200 mg/kg, i.p.
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