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Apexbio Technology LLC Floxuridine 50-91-9 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A24025.1

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Floxuridine is an antineoplastic antimetabolite compound functioning through inhibition of thymidylate synthase leading to interference with thymidine nucleotide biosynthesis This interruption induces DNA replication stress characterized by formation of double-strand DNA breaks Floxuridine exposure activates cellular DNA damage response pathways specifically ATR and ATM kinase signaling cascades and leads to the phosphorylation of checkpoint kinase 1 (Chk1) This compound has been widely utilized in oncology research to analyze DNA damage mechanisms cellular proliferation inhibition and apoptosis induction in human tumor cell lines Floxuridine demonstrates antiproliferative activity in cell-based assays with reported IC50 values typically ranging between 50 nM and 500 nM depending on cell line and experimental conditions

Catalog No. 50-000-62974


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