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Apexbio Technology LLC Fludarabine Phosphate (Fludara)(Synonyms: Fludara, Fludarabine phosphate, Fludarabine monophosphate, 2-Fluoro-ara-AMP), 10mg, CAS: 75607-67-9.
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Supplier:  Apexbio Technology LLC A831710

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Fludarabine phosphate (CAS 75607-67-9) marketed as Fludara is a fluorinated nucleotide analog derived from vidarabine (ara-A) exhibiting antineoplastic activities by interfering with DNA synthesis Following rapid extracellular dephosphorylation to 2-fluoro-ara-A this metabolite is intracellularly phosphorylated by deoxycytidine kinase generating the active triphosphate metabolite 2-fluoro-ara-ATP The active metabolite inhibits critical enzymes including DNA polymerase alpha ribonucleotide reductase and DNA primase thereby disrupting DNA replication and ultimately impeding tumor cell proliferation This compound is broadly utilized in biomedical research focused on anticancer mechanisms and nucleotide metabolism studies

Catalog No. 50-000-60172


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