Apexbio Technology LLC Flumethasone 2135-17-3 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC B17615.1

Flumethasone is a glucocorticoid receptor agonist functioning by binding to intracellular glucocorticoid receptors (GR) and forming a receptor-ligand complex Upon formation this complex translocates into the nucleus modulating transcriptional activity through interactions with glucocorticoid response elements (GREs) subsequently altering gene expression patterns that regulate inflammation immune responses and cellular metabolism Flumethasone is commonly used in biomedical research involving inflammatory and autoimmune disease models to investigate glucocorticoid-mediated regulatory mechanisms receptor signaling pathways and gene expression modulation Reported GR-binding assays indicate Flumethasone exhibits an IC50 value in the low nanomolar range reflecting its potent receptor affinity allowing quantitative analyses and mechanistic studies on glucocorticoid-mediated biological effects

Catalog No. 50-000-63796