Fluocinolone acetonide, Thermo Scientific Chemicals

Description

A glucocorticoid with anti-inflammatory properties

Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Fluocinolone acetonide is primarily used in dermatology to reduce skin inflammation and relieve itching. It acts as an inhibitor of tumor cells and it can regulate lipid metabolism by modulating gene expression. It can also inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, it can inhibit TNF-α angiogenesis.

Solubility
Soluble in water (partly), DMSO, alcohol, chloroform and methanol.

Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 67-73-2
• Molecular Formula: C24H30F2O6
• Molecular Weight (g/mol): 452.50
• MDL Number: MFCD00010525
• InChI Key: FEBLZLNTKCEFIT-VSXGLTOVSA-N
• Synonym: fluocinolone acetonide, synalar, flucinar, synandone, fluonid, jellin, synamol, synemol, coriphate, fluovitif
• PubChem CID: 6215
• ChEBI: CHEBI:31623
• IUPAC Name: (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosa-14,17-dien-16-one
• SMILES: CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

• Melting Point: 267°C to 269°C
• Color: White
• Quantity: 100 mg
• Merck Index: 14,4150
• Solubility Information: Soluble in water (partly),DMSO,alcohol,chloroform and methanol.
• Formula Weight: 452.49
• Physical Form: Crystalline Powder
• Chemical Name or Material: Fluocinolone acetonide

Safety and Handling

Hazard Category	H315-H319-H335-H361
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362-P501c
EINECSNumber	200-668-5
RTECSNumber	TU3830000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only