Fluorescein-Poly GT

Fluorescein-Poly GT

Supplier:  LIFE TECHNOLOGIES PV3610

Catalog No. PV3610

Description

A general fluorescein peptide substrate consisting of a polymer of glutamate, and tyrosine that is used to monitor tyrosine kinase activity.

For use in combination with the LanthaScreen™ Tb-pY20 Antibody (PV3552) to evaluate inhibitors in medium to high throughput screening applications.

Specifications

• Amino Acid Sequence: Fluorescein- Poly Glu:Tyr (4:1)
• Content And Storage: 30 μM Fluorescein Poly-GT peptide substrates in 10 mM HEPES, 137 mM NaCl, 2.7 mM KCl (HEPES buffered saline). Store at -20°C and protect from light.
• Form: Liquid
• Substrate: Fluorescein-Poly GT
• Substrate Type: Kinase Substrate
• Label or Dye: FITC (Fluorescein)
• Target Entry: ABL1 G250E, CSF1R, CSK, EPHA5, KIT, PDGFRA T674I, PDGFRA V561D, PTK6, RET Y791F, SYK, TYRO3, ZAP70, FGFR1, FGFR2, BLK, EGFR, EPHB2, FGFR4, IGF1R, LYNA, MATK, MERTK, NTRK3, RET V804L, ROS1, TEK, TTK, FLT1, MUSK, SRCN1, TEC, ABL1 E255K, BMX, EPHA4, FYN, PTK2, PTK2B, RET, ABL1 T315I, EPHA3, EPHB4, FLT3, FLT4, INSR, LCK, YES1, EGFR L858R, ERBB4, KDR, MET, TNK2, ABL1, ABL2, AXL, FGFR3, FGFR3 K650E, FGR, HCK, KIT V654A, EPHA1, EPHA8, EPHB3, INSRR, LYNB, MST1R, NTRK1, PDGFRA D842V, SRMS, EGFR L861Q, EPHA2, FER, LTK, PDGFRA, PDGFRB, EGFR T790M, EPHA7, EPHB1, MET M1250T, FRK, ITK, FLT3 D835Y, SRC, ABL1 Y253F, BTK, DDR2, FES, KIT T670I, TXK, ERBB2, NTRK2

• Assay Entry: Biochemical terbium phospho-specific activity
• Detection Method: Fluorescence
• Quantity: 1 mL
• Substrate Properties: Peptide-Based Substrate
• Target Enzyme: Tyrosine Kinases
• Shipping Condition: Dry Ice
• Validated Kinases: ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov

For Research Use Only. Not for use in diagnostic procedures.