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Medchemexpress LLC Fluoxetine hydrochloride | 56296-78-7 | 99.97% | 1 ML
Supplier: Medchemexpress LLC HYB0102A10MM/1ML
Fluoxetine hydrochloride is an antidepressant and a selective serotonin reuptake inhibitor.
- Cellular effects (in vitro): Fluoxetine hydrochloride blocks downregulation of cell proliferation induced by inescapable shock in hippocampal cells, increases newborn cells and proliferating cells in the prelimbic cortex, accelerates maturation of immature neurons, and enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. It also increases norepinephrine and dopamine extracellular levels in the prefrontal cortex.
- Animal studies (in vivo): Treatment with fluoxetine hydrochloride reverses deficits in escape latency. Fluoxetine promotes cell proliferation in the dentate gyrus, and coadministration with olanzapine enhances this effect. The combination also leads to substantial increases in extracellular dopamine and norepinephrine levels.
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