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Medchemexpress LLC Flutamide | 13311-84-7 | 99.9% | C11H11F3N2O3 | 500 MG
SDP

Supplier:  Medchemexpress LLC HYB0022500MG

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Flutamide is an Androgen Receptor antagonist with a Ki of 55 nM. It inhibits prostate cancer progression and has shown potential in protecting against hyperthermia-induced multiple organ dysfunction syndrome. The active metabolite, Flutamide-OH, directly binds to the rat anterior pituitary androgen receptor. Flutamide has cytotoxic activity against PC3 and LNCap cells, inducing apoptosis and reducing cell migration and colonization. It downregulates the expression of KLK2 and EMT pathway genes in cells.

  • Androgen receptor antagonist
  • Inhibits prostate cancer progression
  • Protects against hyperthermia-induced multiple organ dysfunction syndrome
  • Exhibits cytotoxic activity against PC3 and LNCap cells
  • Induces apoptosis and reduces cell migration
  • Downregulates KLK2 and EMT pathway genes
  • Significantly reduces rat ventral prostate weight in vivo

Catalog No. 50-004-33534


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