Medchemexpress LLC Fluticasone propionate | 80474-14-2 | 99.9% | 5 MG

Supplier:  Medchemexpress LLC HYB01545MG

Fluticasone propionate is a potent topical anti-inflammatory corticosteroid and a selective glucocorticoid receptor agonist with an absolute affinity (KD) of 0.5 nM. It exhibits minimal or no activity at other steroid receptors and also possesses anti-viral activity.

• Potent topical anti-inflammatory corticosteroid.
• Selective glucocorticoid receptor agonist with a KD of 0.5 nM.
• Exhibits minimal or no activity at other steroid receptors.
• Possesses anti-viral activity.
• Has an EC50 of 0.7 nM for transactivation activity at glucocorticoid receptor in HepG2 cells.
• Shows an ED50 of 3 μg for anti-inflammatory activity in neutrophils.
• Achieves an IC50 of 0.1 nM for inhibition of TNFalpha release in PBMC.
• Demonstrates an EC50 of 1.09 nM for agonist activity at GR in SW1353 cells.
• Inhibits TNFα-induced E-selectin expression with an IC50 of 1 nM.

Catalog No. 50-004-06259