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Medchemexpress LLC Fm-381 | 2226521-65-7 | MFCD31630713 | 99.6% | 428.49 | C24H24N6O2 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY102046100MG

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FM-381 is a small-molecule chemical probe that functions as a potent, covalent reversible inhibitor of JAK3 by targeting the unique Cys909 residue. It exhibits sub-nanomolar potency and strong selectivity versus other JAK family kinases, making it suitable for biochemical and cellular studies of JAK3 signaling.

  • Potent JAK3 inhibition with IC50 = 127 pM
  • High selectivity versus JAK1, JAK2, and TYK2
  • High purity suitable for research use (≈99.6%)
  • Supplied as a solid with DMSO solubility ~8.33 mg/mL
  • Stable storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years)
  • Molecular weight 428.49; formula C24H24N6O2

Catalog No. 50-002-47559


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