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Sigma Aldrich Fmoc-L-Photo-Leucine

Catalog No. 90739150MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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90-739-150MG 10 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Fmoc-L-Photo-Leucine is a diazirine-containing, Fmoc-protected leucine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (≥360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907278.Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coliDeveloping diazirine-based chemical probes to identify histone modification 'readers' and 'erasers'Protein-Polymer Conjugation via Ligand Affinity and Photoactivation of Glutathione S-TransferaseFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Specifications

CAS 945564-85-2
Molecular Formula C20H25BN4O2
Linear Formula C37H56N4O4
Quantity 10 mg
Synonym (1,3,5,5,7,9-hexamethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-10-yl)methyl 1H-imidazole-1-carboxylate; BODIPY Photocage
Molecular Weight (g/mol) 364.25 g/mol
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