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Sigma Aldrich Fmoc-L-Photo-Phe-Oh

Catalog No. 90729450MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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90-729-450MG 50 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

Fmoc-L-Photo-Phe-OH is a diazirine-containing, Fmoc-protected phenylalanine amino acid and multifunctional photo-crosslinker. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (≥360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An unprotected version is also available as 907340.Covalent modifier-type aggregation inhibitor of amyloid-beta based on a cyclo-KLVFF motifMode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass SpectrometryTrifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formationSimple and Versatile Method for Tagging Phenyldiazirine PhotophoresFishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe SynthesisPhoto-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Specifications

CAS 1380314-24-8
Molecular Formula C40H63N7O10S
Linear Formula C78H65ClN2Pd
Quantity 50 mg
Synonym (2S,4R)-1-((S)-27-Azido-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azaheptacosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; (S,R,S)-AHPC-2-2-2-2-2-2-6-N3; Crosslinker-E3 Ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader; VH032 conjugate
Molecular Weight (g/mol) 834.03 g/mol
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