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AdipoGen Fn14 (human):Fc (human) (rec.) (50 µg)
SDP

Supplier:  AdipoGen AG40B0034C050

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Protein. The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.1EU/µg purified protein (LAL test; Lonza). Lyophilized. Contains PBS. Binds to mouse and human TWEAK. Purity: >95% (SDS-PAGE). TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK–Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Catalog No. 50-205-3106


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