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Apexbio Technology LLC Folinic acid 58-05-9 50mg
Supplier: Apexbio Technology LLC B788650
Folinic acid (CAS 58-05-9) also known as leucovorin is a biologically active form of folate present in cellular folate pools typically comprising 10 20% of total folate content Functioning as a cofactor in one-carbon transfer reactions folinic acid bypasses dihydrofolate reductase inhibition to restore nucleotide synthesis In experimental models it mitigates methotrexate-induced chromosomal damage and acts as an anticlastogenic agent by reducing cytogenetic abnormalities Folinic acid is frequently utilized in research as a rescue agent to counteract methotrexate cytotoxicity and to modulate the effects of antifolate chemotherapy agents
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