Selleck Chemical LLC Foretinib (GSK1363089) 50mg 849217-64-7 EXEL-2880,XL-880
Manufacturer: Selleck Chemical LLC S111150MG
Foretinib (GSK1363089, EXEL-2880, XL-880) is an ATP-competitive inhibitor of HGFR and VEGFR, mostly for Met (c-Met) and KDR with IC50 of 0.4 nM and 0.9 nM in cell-free assays. Less potent against Ron, Flt-1/3/4, Kit (c-Kit), PDGFRα/β and Tie-2, and little activity to FGFR1 and EGFR. Phase 2.
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