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Apexbio Technology LLC Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B16345.1
Fosbretabulin (Combretastatin A4 Phosphate CA4P) Disodium (CAS 168555-66-6) is a water-soluble prodrug of combretastatin A4 that acts as a microtubule-destabilizing agent and tumor vascular targeting compound By binding to tubulin CA4P disrupts microtubule dynamics leading to endothelial cell cytoskeletal rearrangement impaired proliferation and migration In vitro CA4P induces myosin light chain phosphorylation actin stress fiber assembly and focal adhesion formation in endothelial cells resulting in vascular shutdown at sub-maximal tolerated doses In vivo studies show significant reduction of tumor functional vasculature and increased tumor necrosis supporting its application in tumor angiogenesis and vascular research
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