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Medchemexpress LLC Fostamatinib disodium hexahydrate | 914295-16-2 | 99.5% | 1 ML
Supplier: Medchemexpress LLC HY13038B10MM/1ML
Fostamatinib disodium hexahydrate is the oral proagent of the active compound R406, an orally available and competitive Syk/FLT3 inhibitor. R406 demonstrates potent inhibition of Syk and FLT3, with additional inhibitory effects on Lyn and Lck. This prodrug is highly bioavailable, rapidly absorbed, and fully converted to R406 in plasma, making it a valuable tool for research applications.
- Oral proagent of active compound R406
- Competitive Syk/FLT3 inhibitor (Ki of 30 nM, IC50 of 41 nM)
- Also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)
- Highly bioavailable and rapidly absorbed
- Completely converted to R406 in plasma
- Exhibits cytotoxicity against human Ramos cells (IC50 = 0.267 μM)
- For research use only
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