Apexbio Technology LLC Fostamatinib (R788) 901119-35-5 10mg

Supplier:  Apexbio Technology LLC B228410

Fostamatinib (R788 CAS 901119-35-5) is an orally available small-molecule inhibitor targeting spleen tyrosine kinase (Syk) with an IC50 of approximately 41 nM As a prodrug fostamatinib is rapidly converted to its active metabolite R406 an ATP-competitive inhibitor of Syk (Ki 30 nM) R406 additionally inhibits related kinases such as Flt3 Lyn (IC50 63 nM) and Lck (IC50 37 nM) thereby modulating BCR- and Fc receptor-mediated signaling pathways Preclinical studies demonstrate activity of fostamatinib in various autoimmune and inflammatory models including SLE-related nephritis and dermatitis in MRL/lpr mice highlighting its utility as a research tool in autoimmune disease investigation

Catalog No. 50-000-62146