Foxp3 Mouse, APC, Clone: 236A/E7, Staining Set, eBioscience
Antibody Staining Kit
Manufacturer: Invitrogen 77577440
DescriptionThis Anti-Human Foxp3 Staining Set contains the buffers and monoclonal antibody necessary to successfully stain and identify Foxp3+ cells. The 236A/E7 monoclonal antibody reacts with human Foxp3, also known as FORKHEAD BOX P3, SCURFIN, and JM2. Foxp3 is a 49-55kDa protein and a member of the forkhead/winged-helix family of transcription factors. It was identified as the gene responsible for the X-linked lymphoproliferative disease observed in scurfy (sf) mice and in the human disorder, X-linked autoimmunity-allergic dysregulation syndrome (XLAAD). Constitutive expression of Foxp3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg), and ectopic expression of Foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.
The 236A/E7 antibody has been shown to crossreact with rhesus macaque, sooty mangabey, and cynomolgus Foxp3. 236A/E7 recognizes a different epitope of Foxp3 than PCH101 and 150D/E4.
|Store at 2-8°C. Light-sensitive material. Use within 6 months of opening or by date indicated on the bottle.|
|Forkhead Box P3, Scurfin, JM2|
|Cynomolgus, Human, Macaque, Monkey, Non-human Primate, Rhesus|
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