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Medchemexpress LLC FPA-124 | 902779-59-3 | C11H9Cl2CuN3O2S | 5 MG
SDP

Catalog No. 5000376269
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FPA-124 is a cell-permeable copper complex that acts as a selective Akt inhibitor with an IC50 of 0.1 μM. It interacts with both the pleckstrin homology (PH) and kinase domains of Akt. FPA-124 has been shown to induce apoptosis and exhibits dose-dependent growth inhibitory effects in various cancer cell lines, with IC50s ranging from 7 to 55 μM. Additionally, in an orthotopic pancreatic tumor model, FPA-124 demonstrated PKB (Akt protein) inhibitory activities and caused NF-κB inactivation.

  • Selective Akt inhibitor with an IC50 of 0.1 μM
  • Induces apoptosis
  • Exhibits growth inhibitory effects in cancer cell lines
  • Demonstrates PKB (Akt protein) inhibitory activities
  • Causes NF-κB inactivation

Catalog No. 50-003-76269 Supplier Medchemexpress LLC Supplier No. HY153695MG
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FPA-124 is a cell-permeable copper complex that acts as a selective Akt inhibitor with an IC50 of 0.1 μM. It interacts with both the pleckstrin homology (PH) and kinase domains of Akt. FPA-124 has been shown to induce apoptosis and exhibits dose-dependent growth inhibitory effects in various cancer cell lines, with IC50s ranging from 7 to 55 μM. Additionally, in an orthotopic pancreatic tumor model, FPA-124 demonstrated PKB (Akt protein) inhibitory activities and caused NF-κB inactivation.

  • Selective Akt inhibitor with an IC50 of 0.1 μM
  • Induces apoptosis
  • Exhibits growth inhibitory effects in cancer cell lines
  • Demonstrates PKB (Akt protein) inhibitory activities
  • Causes NF-κB inactivation

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