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Apexbio Technology LLC FR 180204 865362-74-9 10mg
Supplier: Apexbio Technology LLC A830410
FR 180204 (CAS 865362-74-9) is a small-molecule inhibitor targeting extracellular signal-regulated kinase (ERK) specifically ERK1 and ERK2 It modulates ERK activity thereby regulating MAP kinase signaling pathways FR 180204 exerts its biological activity primarily through ATP-competitive inhibition of ERK1 and ERK2 In in vitro studies FR 180204 demonstrates selective inhibition of ERK1 and ERK2 with IC50 values of 0 31 M and 0 14 M respectively and limited inhibition of related kinases In cell-based assays using Mv1Lu cells it inhibits TGF -induced AP-1 transcriptional activation with an IC50 of approximately 3 1 M Based on these pharmacological properties FR 180204 holds research potential in elucidating ERK-mediated signaling and transcriptional regulation in biomedical studies
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