Cayman Chemical Frtlara thunberg Pemn 50mg

Supplier:  Cayman Chemical 2996350 MG

An alkaloid with diverse biological activities; an inhibitor of Nav1.7 (IC50= 47.2 µM) and hERG (IC50 = 43.7 µM); increases the latent period of coughs, decreases the number of coughs, and has expectorant activity in a mouse model of ammonia liquor-induced cough at 3 mg/kg; inhibits the growth of DU145, LNCaP, and PC3 prostate cancer, but not RWPE-1 non-cancerous, cells at 2.5, 5, and 10 µM; reduces tumor growth in a PC3 mouse xenograft model at 10, 20, or 50 mg/animal; decreases severity of osteoarthritis-associated histopathological alterations in a mouse model of osteoarthritis at 20 mg/kg

Catalog No. 50-298-8771