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Cayman Chemical FruquIntInIb 100mg
Supplier: Cayman Chemical 29425100 MG
A VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively); inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases; inhibits VEGF-A- induced proliferation of HUVECs and VEGF-C-induced proliferation of HLECs (IC50s = 1.7 and 4.2 nM, respectively); decreases tube formation by HUVECs by 74 and 94% at 30 and 300 nM, respectively; reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models at 0.5-20 mg/kg per day for 21 days
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