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Cayman Chemical FSP1 ResazurIn 1ea
SDP

Supplier:  Cayman Chemical 7019041 EA

Encompass_Preferred

A PDE4 inhibitor selective for the PDE4 isoforms PDE4A PDE4B PDE4C and PDE4D (IC50s 0.0832 0.0112 0.2493 and 0.0738 UM respectively) over PDE5A and PDE10A (IC50s 4.793 and 1.4346 UM respectively) and eight other PDEs (IC50s >10 UM for all) increases intracellular cAMP levels in U937 cells at 0.01-10 UM inhibits LPS-induced increases in TNF-a secretion from isolated human and mouse PBMCs (IC50s 19 and 3.5 nM respectively) decreases ear thickness and CD3 T cell eosinophil and neutrophil lesion infiltrates in a mouse model of 246-trinitrochlorobenzene-induced chronic allergic contact dermatitis when applied topically at 3 w/v

Catalog No. 50-289-6931


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