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Cayman Chemical FulacImstat 10mg
Supplier: Cayman Chemical 3773110 MG
A chymase inhibitor (IC50s = 4 and 3 nM for the human and hamster enzyme, respectively); reduces isoprenaline-induced cardiac fibrosis in hamsters at 1, 3, and 10 mg/kg; inhibits decreases in left ventricular ejection fraction and increases in left ventricular end-systolic volume, decreases in plasma levels of nt-proBNP, TGF-β1, and TNF-α, as well as the levels of interstitial fibrosis and the cross-sectional area of myocytes, in a coronary microembolism-induced canine model of heart failure at 2 and 5 mg/kg per day
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