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Enzo Life Sciences Fumonisin B1 (1 mg). CAS: 116355-83-0
Supplier: Enzo Life Sciences BMLSL2200001
A fungal metabolite produced by Fusarium moniliforme. Mycotoxin. Inhibits sphinganine N-acyl-transferase(ceramide synthase)(IC50=0.1µM). Inhibits de novo sphingolipid biosynthesis (IC50=0.7µM for sphingomyelin labeling by [3H]sphinganine, cultured cerebellar neurons). Inhibits growth of axons in cultured hippocampal neurons by blocking glycosphingolipid synthesis. Induces DNA damage in the liver and cancer. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1. Purity: ≥98% (HPLC). Solubility: Soluble in water (25mg/ml). Long Term Storage: -20°C.
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