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Cayman Chemical FungI FuscIn 10mg

Supplier: Cayman Chemical 2748510 MG

A multi-kinase inhibitor inhibits human Aurora kinase B (IC50 250 nM) and the T brucei homolog Aurora kinase-1 (IC50 40 nM) inhibits AMPK LCK MKK1 MAPKAP-K1 CHK1 and PHK in a panel of 25 kinases at 1 UM inhibits MEKK2 in ATPase and transphosphorylation assays (IC50s 60 and 34 nM respectively) induces polyploidy and defects in cytokinesis and spindle assembly as well as inhibits proliferation of HeLa cells and overrides paclitaxel- and monastrol-induced mitotic arrest from 50-100 nM induces toxicity in HepG2 cells (TC50 50 0 22-2 21 UM) inhibits the growth of T brucei L major promastigotes and amasigotes and P falciparum (EC50s 0 01-2 37 UM)
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