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Medchemexpress LLC Furamidine dihydrochloride | 55368-40-6 | 99.0% | 377.27 | 10 MG
Supplier: Medchemexpress LLC HY11013710MG
Furamidine dihydrochloride (DB75 dihydrochloride) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. It exhibits selectivity for PRMT1 over PRMT5, PRMT6, and PRMT4. This compound also acts as a potent, reversible, and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor, with slightly stronger inhibition observed with duplex DNA. It additionally functions as an antiparasite agent. Intended for research use only.
- Selective PRMT1 inhibitor
- Potent, reversible, and competitive TDP-1 inhibitor
- Effective with both single- and double-stranded DNA substrates
- Functions as an antiparasite agent
- Inhibits cell growth in most leukemia cell lines
- Significantly reduces expression level of methylated GFP-ALY protein
- Can intercalate between GC base pairs of duplex DNA
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