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Medchemexpress LLC Furamidine dihydrochloride | 55368-40-6 | 99.0% | 377.27 | 100 MG
Supplier: Medchemexpress LLC HY110137100MG
Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, exhibiting an IC50 of 9.4 μM. It demonstrates selectivity for PRMT1 over PRMT5, PRMT6, and PRMT4. Additionally, it functions as a potent, reversible, and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor, effective with both single- and double-stranded DNA substrates. This compound also possesses antiparasite agent properties.
- Selective PRMT1 inhibitor
- Potent, reversible, and competitive TDP-1 inhibitor
- Effective against single- and double-stranded DNA substrates
- Acts as an antiparasite agent
- Inhibits cell growth in most leukemia cell lines (except HEL cells with JAK2V617F mutations)
- Reduces expression of methylated GFP-ALY protein in 293T cells
- Can intercalate between GC base pairs of duplex DNA
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