Apexbio Technology LLC G-1,10mg CAS# 881639-98-1

Supplier:  Apexbio Technology LLC B545510

G-1 is a potent and selective agonist of GPR30 with EC50 value of 2 nM [1].G protein-coupled receptor 30 (GPR30) is an integral membrane protein that localizes to the endoplasmic reticulum and with high affinity for estradiol and aldosterone. GPR30 participates in multiple intracellular signaling pathways [1].G-1 is a potent and selective GPR30 agonist. In GPR30-expressing cells, G-1 competed binding of the fluorescent estrogen with Ki value of 11 nM, while no substantial binding at concentrations up to 1 μM in ERɑ- and ERβ-expressing cells. In GPR30-expressing COS7 cells, G-1 significantly increased intracellular calcium concentrations with EC50 value of 2 nM in a dose-dependent way. In SKBr3 breast cancer cells that expressed only GPR30, G-1 activated PI3K and resulted in the nuclear accumulation of PIP3 [1]. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-223-9979