Apexbio Technology LLC G-1(Synonyms: G1, G-1 agonist, GPER agonist G-1, GPR30 agonist G-1, GPER-selective agonist G-1), 10mg, CAS: 881639-98-1.

Supplier:  Apexbio Technology LLC B545510

G-1 (CAS 881639-98-1) is a selective agonist for the G protein-coupled receptor GPR30 GPR30 an integral membrane receptor localized within the endoplasmic reticulum binds estradiol and aldosterone and activates various intracellular signaling cascades G-1 binds selectively to GPR30 with a Ki of approximately 11 nM while exhibiting minimal affinity to estrogen receptors ER and ER even at micromolar concentrations Activation of GPR30 by G-1 elevates intracellular calcium concentrations (EC50 2 nM) and induces PI3K-dependent nuclear accumulation of PIP3 In animal models G-1 treatment mitigates myocardial fibrosis modulates -adrenoceptor expression and improves cardiac function suggesting utility in cardiovascular and endocrine research

Catalog No. 50-223-9979