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Medchemexpress LLC G-5555 | 1648863-90-4 | 99.9% | 492.96 | 250 MG
Supplier: Medchemexpress LLC 250MGHY19635
G-5555 is a potent p21-activated kinase 1 (PAK1) inhibitor with Kis of 3.7 nM and 11 nM for PAK1 and PAK2, respectively. It is for research use only and not sold to patients.
- Is a potent PAK1 inhibitor with a Ki of 3.7 nM.
- Exhibits excellent kinase selectivity, inhibiting only eight out of 235 kinases tested other than PAK1 with >70% inhibition.
- Demonstrates high selectivity for group I PAKs.
- Has negligible activity against the hERG channel.
- Shows low blood clearance and an acceptable half-life with high oral bioavailability.
- Imparts 60% tumor growth inhibition in H292 non-small cell lung cancer xenograft studies at 25 mg/kg b.i.d.
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