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Cayman Chemical G6PD ActIvatr AG1 1mg
Supplier: Cayman Chemical 396751 MG
An activator of G6PDH (EC50 = 3.4 µM for G6PDHR459L); selectively induces the dimerization of G6PDHR459L over 6PGD, GAPDH, ALDH2, and ALDH3A1; decreases ROS levels in, and increases the viability of, primary human lymphocytes isolated from a patient carrying the G6PDHR459L mutation; inhibits chloroquine- or diamide-induced hemolysis in isolated human erythrocytes at 5 µM; decreases chloroquine-induced pericardial edema in zebrafish embryos at 1 µM; decreases tumor volume and weight and increases survival in an NCI H226 lung mesothelioma mouse xenograft model at 40 mg/kg
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