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Cayman Chemical G6PD ActIvatr AG1 500ug

Supplier: Cayman Chemical 39675500 UG

An activator of the anticipatory unfolded protein response inhibits protein synthesis and induces intracellular ATP depletion in T47D cells at 1 UM increases levels of phosphorylated EIF2AK3 eIF2a and AMPK in T47D cells at 1 UM cytotoxic to T47D TYS BT474 and ZR-75-1 ERa-positive breast cancer cells (IC50s 16.4 11.1 26.9 and 42.8 nM respectively) induces tumor regression in an MCF-7 mouse xenograft model at 40 mg/kg induces tumor regression in an ST941/HI PDX mouse model
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