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Cayman Chemical G6PDH FluorometrIc Detectr 1ea
Supplier: Cayman Chemical 7002771 EA
A DDR1 inhibitor (IC50 9.4 nM) selective for DDR1 over DDR2 and Abl1 (IC50s 188 and >10000 nM respectively) and 461 additional kinases at 1 UM but does inhibit Cdk11 EPHA8 MUSK TrkA TrkB and TrkC at 1 UM selectively binds to DDR1 (Kd 4.7 nM) over Cdk11 EPHA8 MUSK and TrkA (Kds 370 550 530 and 100 nM respectively) but does bind to TrkB and TrkC (Kds 22 and 18 nM respectively) reduces phosphorylated DDR1 and phosphorylated p38 MAPK levels in primary human lung fibroblasts at 0.25-1 UM reduces bleomycin-induced pulmonary fibrosis in mice at 10 and 50 mg/kg twice per day
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