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Medchemexpress LLC Gala | 107658-43-5 | 99.04% | 3032.36 | 10 MG
SDP

Catalog No. 5000397035
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GALA is a pH-responsive amphipathic peptide composed of 30 amino acids, functioning as a lung endothelium-targeting ligand. It transitions from a random coil to an α-helix in an acidic environment (pH 5.0), leading to endosomal membrane destabilization and fusion. GALA-modified liposomes cross lung endothelial cells via clathrin-dependent endocytosis and transcytosis, accumulating specifically in the lungs after intravenous injection.

  • Enhances cytosolic release of cargos from exosomes, plasmids, and liposomes
  • Improves gene transfection efficiency and drives gene knockdown of functional macromolecules (e.g., siRNA) in alveolar epithelial cells
  • Vital tool for studying lung cancer metastasis and lung-targeted drug delivery systems
  • No significant cytotoxicity at effective concentrations

Catalog No. 50-003-97035 Supplier Medchemexpress LLC Supplier No. HYP542310MG
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GALA is a pH-responsive amphipathic peptide composed of 30 amino acids, functioning as a lung endothelium-targeting ligand. It transitions from a random coil to an α-helix in an acidic environment (pH 5.0), leading to endosomal membrane destabilization and fusion. GALA-modified liposomes cross lung endothelial cells via clathrin-dependent endocytosis and transcytosis, accumulating specifically in the lungs after intravenous injection.

  • Enhances cytosolic release of cargos from exosomes, plasmids, and liposomes
  • Improves gene transfection efficiency and drives gene knockdown of functional macromolecules (e.g., siRNA) in alveolar epithelial cells
  • Vital tool for studying lung cancer metastasis and lung-targeted drug delivery systems
  • No significant cytotoxicity at effective concentrations

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