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Medchemexpress LLC Galanthamine hydrobromide | 1953-04-4 | 99.9% | C17H22BrNO3 | 1 ML
Supplier: Medchemexpress LLC HYA000910MM/1ML
Galanthamine hydrobromide is a selective, reversible, competitive, alkaloid AChE inhibitor (IC50 0.35 μM) and a potent allosteric potentiating ligand (APL) for human α3β4, α4β2, α6β4 nicotinic receptors (nAChRs). It is developed for Alzheimer's disease (AD) research.
- Selective, reversible, competitive, alkaloid AChE inhibitor.
- Potent allosteric potentiating ligand (APL) of human nAChRs.
- Developed for Alzheimer's disease (AD) research.
- Demonstrates 53-fold selectivity for AChE over butyrylcholinesterase.
- Inhibits Aβ 1-40 and Aβ 1-42 aggregation (50 μM).
- Protects against Aβ(1-40) and Aβ(1-42) toxicity in SH-SY5Y cells.
- Reduces Aβ(1-40)-induced cellular apoptosis.
- Reduces cognitive deficits in APP23 mice.
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