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Medchemexpress LLC Galeterone | 851983-85-2 | 99.9% | C26H32N2O | 200 MG
SDP

Supplier:  Medchemexpress LLC HY70006200MG

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Galeterone (TOK-001) is a potent, orally active molecular glue degrader that targets the androgen receptor (AR) and MAP kinase-interacting kinase (Mnk1/2). It also acts as a CYP17 inhibitor. Galeterone induces cell apoptosis and inhibits tumor growth in prostate cancer models, making it suitable for research in castration-resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC).

  • Degrades androgen receptor (AR) and its splice variants (AR-Vs)
  • Degrades MAP kinase-interacting serine/threonine protein kinase Mnk1/2
  • Functions as a CYP17 inhibitor with an IC50 of 47 nM
  • Induces cell apoptosis
  • Inhibits tumor growth in human prostate cancer xenograft mouse models
  • Potentially useful for research in castration-resistant prostate cancer (CRPC)
  • Potentially useful for research in pancreatic ductal adenocarcinoma (PDAC)

Catalog No. 50-004-33581


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