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Tocris Bioscience™ Galiellalactone

Catalog No. 6218500U
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500 μg
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Catalog No. Quantity
62-185-00U 500 μg
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Catalog No. 62-185-00U Supplier Tocris Bioscience™ Supplier No. 6218/500U
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Description

STAT3 inhibitor; active in vivo

Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.

Specifications

Product Type Inhibitor
Target Proteins STAT
CAS 133613-71-5
Molecular Formula C11H14O3
Formula Weight 194.23g/mol
Content And Storage Store at -20°C
For Use With (Application) STAT Inhibitors
Quantity 500 μg

For Research Use Only

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