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Cayman Chemical GambogIc AcId 10mg
Supplier: Cayman Chemical 1476110 MG
A xanthonoid with anticancer activity; binds covalently to SPTSSB (Ki = 1.5 µM; kinact = 0.05 min-1) and inhibits de novo sphingolipid biosynthesis; activates caspases in T47D breast cancer cells (EC50 = 0.78 µM); inhibits binding of anti-apoptotic proteins to a BH3 peptide (IC50s = 1.47, 1.21, 2.02, 0.66, 1.06, and 0.79 μM for Bcl-xL, Bcl-2, Bcl-W, Bcl-B, Bfl-1, Mcl-1, respectively); binds to the transferrin receptor (IC50 = 4.1 µM); reduces growth of a variety of cancer cell lines (GI50s = 0.115-1 µM) and induces apoptosis in T47D cells; a slow inhibitor of inward-rectifying potassium channel 2.1 (Kir2.1; IC50 = <0.1 µM)
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