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AdipoGen Ganglioside GM1 Na bovine
Supplier: AdipoGen AGCN29000M010
Chemical. CAS 37758-47-7. Formula C73H130N3O31 . Na. MW 1545.8 . 23.0 calculated on sphingosine C181 and stearic acid. Isolated from bovine brain. Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types.
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