Apexbio Technology LLC GANT61 500579-04-4 10mM (in 1mL Ethanol)

Supplier:  Apexbio Technology LLC A16155.1

GANT61 (CAS 500579-04-4) is a selective inhibitor targeting GLI transcription factors downstream effectors of the canonical Hedgehog (HH) signaling cascade HH signaling mediates crucial developmental processes and differentiation while abnormal activation of GLI transcription factors (GLI1 GLI2) contributes to oncogenesis GANT61 inhibits GLI-mediated transcriptional activity demonstrated by inhibition of cell proliferation (IC50 values around 7 96 13 56 M) and induction of cell-cycle arrest and apoptosis in cancer cell lines (e g neuroblastoma rhabdomyosarcoma) In vivo studies using xenograft tumor models indicate suppression of tumor growth highlighting GANT61 s role in oncology research investigating GLI-dependent pathways

Catalog No. 50-000-63059