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Medchemexpress LLC Garcinone D | 107390-08-9 | 10 MM 1 ML
Supplier: Medchemexpress LLC HYN695310MM/1ML
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM). It promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression, and enhancing the Nrf2/HO-1 signaling pathway. Additionally, it blocks the tumor cell cycle by inhibiting CDK2/CyclinE1 and can inhibit prostate and breast cancer.
- Activator of STAT3/Cyclin D1 and Nrf2/HO-1 pathways
- Inhibitor of CDK2/CyclinE1
- Promotes neural stem cell proliferation
- Blocks tumor cell cycle
- Regulates C17.2 neural stem cell viability
- Promotes G1-S phase transition and arrests cell cycle in S phase in C17.2 neural stem cells
- Increases p-STAT3, Cyclin D1, Nrf2, and HO-1 proteins in C17.2 neural stem cells
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