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AdipoGen GBP1 human pAb IN111
Supplier: AdipoGen AG25B6001C050
Polyclonal antibody. Recognizes endogenous human GBP1. Application WB. Source Rabbit. Liquid. In PBS containing 0.05% sodium azide. Guanylate-binding proteins GBPs are a family of antimicrobial proteins that are expressed by host cells in response to pathogens. Expression of GBPs is induced by both type I IFNs and IFN-gamma. During infection with pathogen S. Typhimurium or Salmonella, GBP1 binds first to surface of the bacteria, leading to the recruitment of GBP2, GBP3 and GBP4. GBP1 binds to the component LPS Lipopolysaccharide of the bacteria as a first step bringing caspase-4 to the surface of bacteria, leading to caspase-1 activation, Gasdermin D cleavage and finally pyroptotic cell death. GBP1 is cleaved and inactivated by Caspase-1. GBP1 also promotes Toxoplasma DNA detection by AIM2-ASC-Caspase-8 leading to apoptosis. GBP1 acts as a gatekeeper of cell death pathways, which respond specifically to infecting microbes.
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